(June 22, 2020) AMA with Dom D’Agostino, Ph.D., Part I of II: Ketogenic diet, exogenous ketones, and exercise.(July 16, 2018) Dom D’Agostino, Ph.D.: ketosis, n=1, exogenous ketones, HBOT, seizures, and cancer.Dom’s post doc work involved studying seizures.Check out more content with Dom D’Agostino:.Turned on to it in 2007 on a nutrition forum.As we age, glucose energy metabolism tends to decrease, but ketone energy metabolism tends to stay constant. Ketones, on the other hand, completely bypass this conversion step. This enzyme helps convert pyruvate (which gets converted from glucose) into acetyl CoA which is in turn used to make ATP. Many people have an impaired PHD enzyme (Pyruvate Dehyrogenase), such as people with Alzeimer’s Disease.Your brain can create ATP more efficiently from ketones compared to glucose.As we age, we become more carbohydrate intolerant and insulin resistant, so the benefits of the ketogenic diet increase as we age.There is no rise and fall of glucose which makes us moody, hungry etc.We control our appetite instead of our appetite controlling us.The ketogenic diet works well because its non-glycemic.This occurs due to the lack of glucose swings.Many people report not feeling any sort of “crash” after large meals on the ketogenic diets.Dom recommends consuming creatine phosphate (~3g a day) daily to help create those short bursts of power.However, you should be fine most of the time producing ATP for those short bursts of power you need, as long as you are consuming significant fat calories.Because of this, before heavy training (cycling, MMA), it might make sense to consume some sort of low glycemic, high molecular weight carbohydrates (sweet potatoes, yams).The body is very adaptable to switching fuel sources (fat and glucose).This has around 90% of the benefits of the traditional ketogenic diet and is what Dom follows. The modified ketogenic (or modified Atkins) diet involves consuming ~70% fat, 20-30% protein, and other non glycemic vegetables.The strict ketogenic diet involves consuming about 90% of your calories from fat and 10% from protein/carbs.Essentially the ketone bodies replace glucose.Insulin is released by our pancreas to help shuttle the glucose that we eat into cells.The ketogenic diet mimics the physiological state of fasting by supressing insulin and raising blood ketone levels.Ketones are produced by the liver from fat (either from our own body fat during fasting, or the fat we eat) and are used, instead of glucose, to create ATP (energy).Ketosis is when you have a blood concentration of ketones greater than or equal to 0.5mmol.It was observed long long ago that fasting (for 2-3 days) was a cure for seizures, as fasting puts you into a state of fasting ketosis.Where It Happens with Sahil Bloom and Greg Isenberg.This Week in Startups with Jason Calacanis.
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